钱旭红
钱旭红(1962年——),男,江苏宝应人,博导、教授、“973”首席科学家、中国工程院院士、国家自然科学基金化学部咨询委员、英国皇家化学会会士、德国洪堡基金会学术大使,现任华东师范大学校长。
长期从事有机化工领域的应用基础与工程技术研究和开发工作。以氟化和芳杂化为主线,深入开展了含特殊官能团、活性功能团有机化学品的分子设计、合成制备、结构功能及产业化应用。开发出多氟芳酸等制备的绿色高效关键技术;创制新机制、性能独特的顺硝烯杂环类和含氟类绿色化学农药; 创制分子识别传感和检测分离一体化的萘酰亚胺等芳杂环类荧光功能染料。发表SCI论文275篇,EI论文64篇;获得中国发明专利19项、国际PCT专利和美、欧、日专利共12项。若干技术实现产业化或工业化实施,取得显著的社会经济效益。 研究成果(第一完成人)获得国家科技进步二等奖1项、上海市自然科学一等奖1项、教育部科技进步一等奖3项。
2011年当选为中国工程院院士。
人物履历
1978.9 进入华东化工学院(现华东理工大学)石油化工系,1982.7 获学士学位;
1982.9 华东化工学院(现华东理工大学)精细化工系研究生,1985.4 获硕士学位;
1988.7 华东理工大学获工学博士学位;
1989.8-1990.8 受美国Welch基金会资助,到美国德克萨斯州拉玛大学Research Associate,从事博士后研究,期间他从事了昆虫生长调节剂的研究工作;
1990.9-1991.12 德国巴伐利亚州维尔兹堡大学洪堡基金(AvH)博士后,从事DNA嵌入剂、切断荆的研究;
1988-1992.4 华东理工大学讲师;
1992.8-1994.7 副教授;1994.8至今,教授;
1995.12至今,博士生导师。
1986-1987华东理工大学精细化工系党总支副书记;
1992.8-1995.4先后任华东理工大学精细化工学科主任、药物化工研究所所长;
1995.5-7国家高级教育行政学院学员;
1995.9-1996.2任华东理工大学校长助理;
1996.3-2000.10 任华东理工大学副校长;
2002.1-2010.1上海市化学生物学重点实验室主任(兼);
2003.3-2006国家南方农药创制中心(上海)主任(兼)。
2004.7-2015.3华东理工大学校长。
2007.4- 中国化工学会副理事长;
2007-2008,亚洲及太平洋化工联盟主席。
2018.1-?华东师范大学校长
2011.12 当选中国工程院院士(化工、冶金与材料工程学部)。
2018年1月,华东师范大学校长、党委委员、常委、党委副书记。
2020年10月,担任教育部基础教育教学指导委员会委员。
任免信息
2018年1月17日,华东师范大学召开学校干部大会,宣布教育部关于华东师范大学校长的任免决定:钱旭红担任校长。
研究课题
研究方向
钱旭红主要研究方向,包括:是生物有机化学,化学生物技术与工程,其研究工作主要体现在用作农药先导、荧光传感器、抗癌先导、人工核酸酶、细胞激活剂的芳香杂环分子设计、合成、构效关系及生物应用。具体研究方向:
研究方向1.染料的化学生物学
其研究主要体现在荧光传感器与抗癌先导,包括以下内容:
荧光传感器:由萘,萘酰亚胺,香豆素,氟硼吡咯,聚合物衍生的高选择性汞离子铜离子锌离子银离子荧光传感器,某些阴离子荧光传感器,以及其它的荧光探针,荧光标记。
抗癌先导:由硫化合物,噻类芳香杂环,羰酰亚胺,萘酰亚胺,萘内酰胺、苯并吲哚酚嗪,吖啶,苊萘醌,苊萘吡咯羰腈,酞菁等衍生的抗癌试剂,BCL蛋白与细胞调亡剂,拓扑异构酶抑制剂、光动力治疗剂,色素的药物化学(抗肿瘤先导、DNA嵌入剂、细胞调亡剂)
研究方向2.农药的化学与生物学
其研究主要体现在芳香杂环或氟化合物衍生的农药先导,包括以下内容:
农药先导:昆虫生长调节剂、昆虫行为调节剂、几丁质合成抑制、蜕皮激动、飞行调控、海藻糖酶抑制,拒食,尼古丁受体激动,杀虫剂,除草剂,杀菌剂。
新杂环化合物:氟化合物,氟烷氧基化合物,芳香杂环,硫化合物,恶二唑、噻二唑、哒嗪酮、新烟碱、环亚胺、二芳酰基肼
研究方向3. 化学生物技术与工程
其研究主要体现在人工核酸酶,细胞激活剂和生物转化,包括以下方面:
人工核酸酶:由萘酰亚胺、硫杂环衍生的人工光核酸酶,光降解,人工核酸水解酶,DNA切断剂,生物制备过程中转基因物质的去除。
细胞激活剂:由茉莉酮酸酯、苯并噻二唑等衍生的细胞激活剂,用于人参、紫杉烷、灵芝的次生代谢物的增产与调控。
生物转化:酵母,植物细胞,立体选择性还原,化学选择性还原,芴,芳香硝基、胺、羟胺、酮还原、手性醇。
研究成果
上地幔变形作用和地球化学性质之间的关系及其深部动力学意义。运用综合研究方法,探讨了伊通新生代玄武岩中特有的具糜棱结构的橄榄岩包体所经历的构造热演化及动力学,证实了上地幔韧性剪切带的存在。强调其形成与超大断裂活动性之间的关系;并首次发现了橄榄岩包体中矿物颗粒间的氧同位素不平衡现象,为地幔剪切变形和地幔交代作用提供了时间约束,认为流体的存在并不是剪切变形的先决条件,从而为地幔学术界长期争论的流体和地幔变形之间的因果关系提供了新的判别依据。根据吉林汪清尖晶石相橄榄岩包体结构、平衡温度、主元素亏损程度和不相容元素富集程度之间的相关关系,提出了上地幔底辟上升和热扩散平衡的动力学模式,阐明了不同结构类型包体在底辟体中的空间展布及其对交代流体迁移的控制。认为所有研究样品均来自岩石圈地幔,但由于下伏软流圈的上涌而导致其流变学性质的改变,从而同软流圈一起发生底辟。这一成果为华北自中生代以来发生的大规模热侵蚀-减薄机制提供了一个可行的动力学模式。
上地幔熔体-岩石反应机理及其微量元素理论模拟通过对伊通含富钾硅酸盐玻璃体的异剥橄榄岩和法国中央高原具镶嵌结构I型尖晶石相方辉橄榄岩包体的研究,橄榄岩包体的研究,鉴定出了单斜辉石生成反应和橄榄石生成反应两个系列。这是对构造橄榄岩体研究的重要补充,对地幔不均一性及岩浆源区混合作用的研究具有重要意义。后者还提供了岩石圈最底部-地幔热柱相互作用的证据。运用0-维数值模型计算了微量元素在上地幔熔体迁移/反应过程中地球化学行为。该成果对认识熔体/流体在深部岩石圈地幔演化过程中的作用具有重要意义。
地幔地质温压计的检测,应用和中国东部地幔岩石圈热演化系统总结和科学评价了常用的二十多种温度计和五种压力计的优缺点,为国内学者更加审慎地选用温压计提供了依据,在此基础上,探讨了中国东部上地幔热结构和热演化历史。以在特定热演化阶段中古老岩石圈/软流圈相互作用程度为思路,结合实验岩石学资料和岩石圈拉张历史,提出了一个热-构造演化模式,从而比较合理地解释了中国东部中生代末期-新生代玄武岩的岩性,微量元素和同位素地球化学演化特征,为深部地幔研究提供了新思路。
中国东部幔源橄榄岩的铂族元素地球化学研究在国内率先开展了中国东部幔源橄榄岩的PGE地球化学研究,填补了中国在地幔岩PGE研究领域的空白。初步了解了不同类型岩石中这些元素的丰度和分布规律,揭示了中国东部上地幔特有的PGE分配型式(即富集Pt,亏损Ir和Pd)。探讨了PGE在多种重要上地幔过程中的地球化学行为。
荣誉成就
1992?霍英东基金会高校优秀青年教师奖(科研类);
1995 全国优秀教师;
1996?国务院政府特殊津贴;
1997 入选国家百千万人才工程(第一、二层次);
1998 中国青年科技奖;
1999 第六届上海十大科技精英;
1994 国家教委科技进步一等奖(第二完成人);
1998 上海市科技进步三等奖(第一完成人);
1998 国家教育部科技进步一等奖(第一完成人);
2002 国家教育部科技进步一等奖(第一完成人);
2003 国家教育部自然科学一等奖(第一完成人)。
2000 国家杰出青年科学基金获得者;
2001 大连市优秀专家;
2001-?中国化工学会农药委员会副主任委员。J. Fluorine Chemistry,Pesticide Biochemistry and Physiology等编委,在ChemCommun.,Org.Lett.,JACS等?SCI?国际学报发表论文近百十篇。专利十数项。此外,
2003 担任国家重点基础研究发展规划(973计划) 项目首席科学家;
2003-?国务院学位委员会学科评议组成员;
2004-?国家自然科学基金委员会第十届有机化学评议组成员,第十一届化工评议组成员。
2007. 3- 亚洲及太平洋化工联盟主席。
2011 中国工程院院士。
学术论文
研究方向1.染料的化学生物学
ORG. LETT.-2006-3721: A series of polyamide receptor based PET fluorescent sensor molecules: Positively cooperative Hg2+ ion binding with high sensitivity
ORG. LETT. 2005-3029: Colorimetric and ratiometric fluorescent chemosensor with a large red-shift in emission: Cu(Ⅱ)-only sensing by deprotonation of secondary amines as receptor conjugated to naphthalimide fluorophore
ORG. LETT.-2005-889: Ratiometric and selective fluorescent sensor for Cu-Ⅱ based on internal charge transfer (ICT)
ORG. LETT. 2004-2757: Novel fluorescent pH sensors based on intramolecular hydrogen bonding ability of naphthalimide (SS)
J. ORG. CHEM.-2006-4308: Detecting Hg2+ ions with an ICT fluorescent sensor molecule: Remarkable emission spectra shift and unique selectivity
J. ORG. CHEM.-2007-3554: Ratiometric and highly selective fluorescent sensor for cadmium under physiological pH range: A new strategy to discriminate cadmium from zinc
CHEM. COMMUN.-2006-109: Two regioisomeric and exclusively selective Hg(Ⅱ) sensor molecules composed of a naphthalimide fluorophore and an o-phenylenediamine derived triamide receptor
CHEM. COMMUN.-2005-239: A new class of long-wavelength fluorophores: strong red fluorescence,convenient synthesis and easy derivation
CHEM. COMMUN.-2001-2656: Intramolecular aromatic 1,5-hydrogen transfer in preparation of oxacyclic naphthalic anhydride via unusual Pschorr cyclisation
NEW J. CHEM.-2003-337: A polyamidoamine dendrimer with peripheral 1,8-naphthalimide groups capable of acting as a PET fluorescent sensor for metal cations
NEW J. CHEM.-2002-920: Novel heterogeneous PET fluorescent sensors selective for transition metal ions or protons: polymers regularly labelled with naphthalimide
J. AM. CHEM. SOC.-2004-2272: A highly selective and sensitive fluorescent chemosensor for Hg2+ in neutral buffer aqueous solution
KIDNEY INTERNATIONAL-2004-2279: Fluorescent imaging of acute mercuric chloride exposure on cultured human kidney tubular epithelial cells
CHEM. RES. TOⅪC.-2005-1814: Visible study of mercuric ion and its conjugate in living cells of mammals and plants
CHEMBIOCHEM-2007-113: Novel Bcl-2 inhibitors: Discovery and mechanism study of small organic apoptosis-inducing agents (SS)
J. MATER. CHEM. -2005-2836: A pH-resistant Zn(Ⅱ) sensor derived from 4-aminonaphthalimide: design,synthesis and intracellular applications
MOL. CANCER THER.-2007-484: R16,a novel amonafide analogue,induces apoptosis and G2-M arrest via poisoning topoisomerase Ⅱ (SS)
BIOORG. MED. CHEM. LETT.-2006-1562: Synthesis and evaluation of novel 8-oxo-8H-cyclopenta[a]acenaphthylene-7-carbonitriles as long-wavelength fluorescent markers for hypoxic cells in solid tumor
BIOORG. MED. CHEM. LETT.-2005-5909: Novel synthetic isoquinolino[5,4-ab]phenazines: Inhibition toward topoisomerase I,antitumor and DNA photo-cleaving activities
BIOORG. MED. CHEM. LETT.-2005-4864: Novel thiazonaphthalimides as efficient antitumor and DNA photocleaving agents: Effects of intercalation,side chains,and substituent groups (SS)
BIOORG. MED. CHEM. LETT.-2005-4864: Synthesis,antitumor evaluation and DNA photocleaving activity of novel methylthiazonaphthalimides with aminoalkyl side chains (SS)
BIOORG. MED. CHEM. LETT.-2005-1139: Five-member thio-heterocyclic fused naphthalimides with aminoalkyl side chains: intercalation and photocleavage to DNA (SS)
BIOORG. MED. CHEM. LETT.-2003-5427: Novel naphthalimide hydroperoxide photonucleases: The role of thiocyclic-fused area and the difference in spectra,photochemistry and photobiological activity (SS)
BIOORG. MED. CHEM.-2007-1356: Novel antitumor agent family of 1H-benzo[c,d]indol-2-one with flexible basic side chains: Synthesis and biological evaluation (SS)
BIOORG. MED. CHEM.-2006-6962:Acenaphtho[1,2-b]pyrrole derivatives as new family of intercalators: Various DNA binding geometry and interesting antitumor capacity (SS)
BIOORG. MED. CHEM.-2006-4639: Design,synthesis,and antitumor evaluation of novel acenaphtho[1,2-b]pyrrole-carboxylic acid esters with amino chain substitution (SS)
BIOORG. MED. CHEM. -2005-3149: Novel heterocyclic family of phenyl naphthothiazole carboxamides derived from naphthalimides: synthesis,antitumor evaluation,and DNA photocleavage (SS)
BIOORG. MED. CHEM.-2005-1615: Thio-heterocylic naphthalimides with aminoalkyl side chains: novel alternative tools for photodegradation of genomic DNA without impairment on bioactivities of proteins (SS)
TETRAHEDRON LETT.-2005-6289: A proton sponge-based fluorescent switch
TETRAHEDRON LETT.-2004-3969: A novel chromatism switcher with double receptors selectively for Ag+ in neutral aqueous solution: 4,5-diaminoalkeneamino-N-alkyl-1,8-naphthalimides
TETRAHEDRON LETT.-2003-2087: Novel highly efficient fluoroionophores with a peri-effect and strong electron-donating receptors: TICT-promoted PET and signaling response to transition metal cations with low background emission
TETRAHEDRON LETT.-2003-795: Promoting effects of the hydroxymethyl group on the fluorescent signaling recognition of anions by thioureas
TETRAHEDRON LETT.-2002-2991: 4-Amino-1,8-dicyanonaphthalene derivatives as novel fluorophore and fluorescence switches: efficient synthesis and fluorescence enhancement induced by transition metal ions and protons
TETRAHEDRON LETT.-2002-2995: Synthesis and properties of benzothioxanthene dicarboximide hydroperoxide: an efficient 'time-resolved' DNA photocleaver with long-wavelength (SS)
TETRAHEDRON LETT.-2001-6175: N-aroyloxynaphthalimides as novel highly efficient DNA photocleavers: substituent effects
TETRAHEDRON LETT.-2000-7711: Novel and highly efficient DNA photocleavers: hydroperoxides of heterocyclic-fused naphthalimides
TETRAHEDRON-2005-11895: Novel DNA bis-intercalators of isoquinolino[4,5-bc]acridines: design,synthesis and evaluation of cytotoxic activity
TETRAHEDRON-2005-8717: Synthesis,antitumor and DNA photocleaving activities of novel naphthalene carboxamides: effects of different thio-heterocyclic rings and aminoalkyl side chains (SS)
TETRAHEDRON-2005-6634: Synthesis of thiazo- or thiadiazo- naphthalene carboxamides via mercuric intermediates and their antitumor and DNA photocleavage activities (SS)
TETRAHEDRON-2006-10117: Exploiting the deprotonation mechanism for the design of ratiometric and colorimetric Zn2+ fluorescent chemosensor with a large red-shift in emission
DYES PIGMENTS-2002-247: Synthesis and properties of oligonucleotides containing fluorescent ethenodeoxyadeno sine and ethenodeoxycytidine
DYES PIGMENTS-2001-51: Absorption and fluorescence spectral properties of tetra (fluoroalkoxy) metallophthalocyanines (FF)
DYES PIGMENTS-2001-43: Oxazolonaphthalimides and their hydroperoxides: photophysical and photobiological properties
DYES PIGMENTS-2004-9: Benzothioxanthene dyes as fluorescent label for DNA hybridization: synthesis and application (SS)
DYES PIGMENTS-2004-17: Synthesis and peroxidase-staining properties of novel water soluble polyhydroxylalkyl benzidine dyes
J. FLUORINE CHEM.-2002-161: Synthesis and photosensitizing properties of fluoroalkoxyl phthalocyanine metal complexes (FF)
J. FLUORINE CHEM.-2000-69: Synthesis of fluorine-containing oxazolonaphthalimide hydroperoxides as DNA photocleavers (FF)
CHINESE J. ORG. CHEM.1997-329: Synthesis and characterizations of the dye sensitized photooxygenation products and the heterocycles of naphthofuran derivatives
CHINESE J. ORG. CHEM.-1997-428: Synthesis,characterization and DNA intercalation of a furonaphthopyronone as a novel analogue of furocoumarin
CHINESE J. ORG. CHEM.-2000-338: Synthesis and structure characterization of two thienonaphthopyrones (SS)
CHINESE J. ORG. CHEM. 2006-504: Synthesis and properties of N-butyl-4-(aza-15-crown-5)-1,8-naphthalimide as a fluorescent probe
CHEM. RESEARCH IN CHINESE UNⅣ.-2005-480: A novel photocleaver with long wavelength absorption – Highly efficient antitumor agent: 4-(2-diethylamino -ethylamino)-8-oxo-8H-acenaphtho-[ 1,2-b] pyrrole-9-carbonitrile
CHEM. J. CHINESE UNⅣ.-1996-1399: Syntheses,DNA Intercalation Activities and Molecular Modelling on Structures of Tatramethyldifuronaphthalenes
J. PHOTOCHEM. PHOTOBIO. B-2001-35: Tetra-trifluoroethoxyl zinc phthalocyanine: potential photosensitizer for use in the photodynamic therapy of cancer (SS)
J. PHOTOCHEM. PHOTOBIO. B-2006-221: Isoquino[4,5-bc]acridines: Design,synthesis and evaluation of DNA binding,anti-tumor and DNA photo-damaging ability
J. CHEM. SOC.-PERKIN TRANSACTIONS 2-2000-715: Interaction of naphthyl heterocycles with DNA: effects of thiono and thio groups (SS)
MONATSH CHEM.-1999-1109: Synthesis of novel DNA-intercalating naphthopyrone derivatives with improved water solubility and photophysical properties
BULL. CHEM. SOC. JAPAN-1999-1571: Highly efficient photoinduced DNA cleavage by naphthopyrone hydroperoxides
CHEM. LETT.-2005-696: Novel naphthalimide fluorescent sensors selective for certain proteins on basis of non-covalent interactions between enzyme and inhibitor (SS)
SYNTHESIS-STUTTGART-1999-1109: General synthesis of thioxo-1,8-naphthalimides via thioxo-1,8-naphthalic anhydrides (SS)
HETEROATOM CHEM.-1999-141: The improved synthesis,Diels-Alder reactions,and desulfuration of trithio-1,8-naphthalic anhydride (SS)
POLYMER-2002-5731: Synthesis and photophysical properties of 1,8-naphthalimide-labelled PAMAM as PET sensors of protons and of transition metal ions
CHINESE J. ANAL. CHEM. -2004-837: Studies on the room temperature phosphorescence of halogen naphthalic anhydrides
CHINESE CHEM. LETT.-2004-118: Anthracylmethyl benzoazacrown ether as selective fluorescence sensors for Zn2+
HETEROCYCL. COMMUN.-2003-229: A new class of DNA intercalator and photocleaver: Bis-naphthailimides with bromo and nitro substituents
MONATSH. CHEM.-2003-393: New fluorescent conjugates of uridine nucleoside and substituted 1,8-naphthalimide: Synthesis,weak interactions and solvent effects on spectra
INT. J. BIO. MACROMOL.-2006-59: Study on the interaction between 4-(2-diethylanuno- ethylamino)-8-oxo-8H- acenaphtho[1,2-b]pyrrole-9-carbonitrile and DNA by molecular spectra
研究方向2.农药的化学与生物学
J. AGRI. FOOD CHEM.-2007-2288: Synthesis,insecticidal activity,and QSAR of novel nitromethylene neonicotinoids with tetrahydropyridine fixed cis configuration and exo-ring ether modification
J. AGRI. FOOD CHEM.-2006-125: Synthesis and herbicidal activity of novel 3-aminocarbonyl-2-oxazolidinethione derivatives containing a substituted pyridine ring
J. AGRI. FOOD CHEM.-2006-8793: Novel,unnatural benzo-1,2,3-thiadiazole-7-carboxylate elicitors of taxoid biosynthesis (SS,FF)
J. AGRI. FOOD CHEM.-2005-3120: Syntheses,antifeedant activity,and QSAR analysis of new oxa(thia)diazolyl 3(2H)-pyridazinones (SS)
J. AGRI. FOOD CHEM.-2005-3120: Syntheses,Antifeedant Activity,and QSAR Analysis of New Oxa(thia)diazolyl 3(2 H)-Pyridazinones (SS)
J. AGRI. FOOD CHEM.-2003-152: Synthesis and Antifeedant Activity of New Oxadiazolyl 3(2H)-Pyridazinones
J. AGRI. FOOD CHEM.-2001-124: Synthesis and Quantitative Structure-Activity Relationships of New 2,5-Disubstituted-1,3,4-oxadiazoles (FF)
J. AGRI. FOOD CHEM.-2001-5279: Synthesis and Quantitative Structure-Activity Relationships of Fluorine-Containing 4,4-Dihydroxylmethyl-2-aryl imino- oxazo (thiazo)lidines as Trehalase Inhibitors (SS,FF)
J. AGRI. FOOD CHEM.-1999-4415: Quantitative studies on structure-activity relationship of sulfonylurea and benzoylphenylurea type pesticides and their substituents' bioisosterism using synthons' activity contribution (SS,FF)
J. AGRI. FOOD CHEM.-1996-1538: Molecular modeling study on the structure-activity relationship of substituted dibenzoyl-1-tert-butylhydrazines and their structural similarity to 20-hydroxyecdysone
ACS SYMPOSIUM SERIES-2005(892)-273: Oxadiazole derivatives as novel insect-growth regulators: Synthesis and structure-bioactivity relationship (FF)
J. FLUORINE CHEM.-2006-182: Synthesis and herbicidal activities of fluorine-containing 3-pyridylmethyl-2- phenyliminothiazolidine derivatives (SS,FF)
J. FLUORINE CHEM.-2005-297: Synthesis and fungicidal activity of fluorine-containing phenylimino-thiazolidines derivatives (SS,FF)
J. FLUORINE CHEM.-2005-53: Synthesis and biological activities of hydroxyl-protected fluorine-containing 4,4-dihydroxylmethyl-2-aryl-iminothiazolidines (SS,FF)
J. FLUORINE CHEM.-2004-1159: Synthesis and fungicidal activity of Fluorine-containing Phenylimino-thiazolidines Derivatives (SS,FF)
J. FLUORINE CHEM.-2004-1609: Syntheses,structures and bioactivities of fluorine-containing phenylimino-thia(oxa)zolidine derivatives as agricultural bioregulators (SS,FF)
J. FLUORINE CHEM.-2003-163: Synthesis and insecticidal activities of novel 2,5-disubstituted 1,3,4-oxadiazoles (FF)
J. FLUORINE CHEM.-2003-51: Synthesis and insecticidal activity of new substituted N-aryl-Nu2019-benzoylthiourea compounds (SS,FF)
J. FLUORINE CHEM.-2002-63: Syntheses and insecticidal activity of new 2-(5-(trifluoromethyl)pyridyloxymethyl) -1,3,4-oxadiazoles] (FF)
J. FLUORINE CHEM.-2000-111: Fluorine containing heterocyclic compounds: synthesis of 6-substituted-2-substituted-aryl-1,2,4-triazolo[5,1-b] 1,3,5- thia- diazin-7-one derivatives (SS,FF)
J. FLUORINE CHEM.-2000-173: Syntheses and insecticidal activities of novel 2-fluorophenyl-5-aryl/cyclopropyl-1,3,4-oxadiazoles (FF)
J. FLUORINE CHEM.-2001-143: Synthesis and biological activities of fluorine-containing N,Nu2019-diphenylcarbamimidothioates (SS,FF)
J. FLUORINE CHEM.-1999-39: Syntheses and characterization of 2-amino-5-aryl-1,3,4-oxadiazoles containing trifluoroethoxy groups (FF)
J. FLUORINE CHEM.-1998-9: Polyfluoroalkoxylation and methoxylation of polychloropyridines (FF)
J. FLUORINE CHEM.-1996-9: Alcoholysis of trifluoromethyl groups attached to the pyridine ring (FF)
J. FLUORINE CHEM.-1991-143: A synthetic and MO-SCF study of the trifluoroethoxylation of chloro(trifluoromethyl)pyridine derivatives (FF)
CHEM. PHYS. LETT.-2003-489: Intramolecular noncovalent force in cyclic amidines: nonbonded interaction between carbon atoms and heteroatoms (SS,FF)
PEST. MANAG. SCI. -2003-933: The toxic and anti-feedant activity of 2H-pyridazin-3-one-substituted 1,3,4-oxadiazoles against the armyworm Pseudaletia separata (Walker) and other insects and mite
CARBOHYDRATE RESEARCH-2001-79: Syntheses and activities as trehalase inhibitors of N-arylglycosylamines derived from fluorinated anilines (FF)
J. CHEM. TECH. BIOTECH.-1996-124: Syntheses and insecticidal activities of novel 2,5-disubstituted-1,3,4-oxadiazoles (FF)
CAN. J. CHEM. -2003-272: N'-tert-Butyl-N'-aroyl-N-(alkoxycarbonylmethyl)-N-aroylhydrazines,a novel nonsteroidal ecdysone agonist: syntheses,insecticidal activity,conformational and crystal structure analysis
MONATSH CHEM.-2006-779: An efficient and practical method for the synthesis of 1-(2,6-difluorobenzoyl)-3-(2-alkyl-3-oxopyridazin-4-yl)ureas as potential chitin synthesis inhibitors (FF)
MONATSH CHEM.-2000-953: Novel fused heterocycles: Synthesis and activity of 5,6-dihydro-7-thia-1,3,3a,5-tetraazainden-4-one and 1-thia-3,4a,9-triazafluoren-4-one derivatives (SS)
J. CHEM. RES.-2006- 626: Synthesis and bioactivities of novel neonicotinoids dioxolane compounds
J. CHEM. RES.-2000-88: The crystal structure of 1-phenyl-3-methyl-5-[2 '-(4 ''-phenylmethoxylphenyl)ethoxyl]pyrazole,a potential insect juvenile hormone mimic
J. CHEM. RES.-1999-66: The crystal structure of N-(5-phenyl-1,3,4-oxadiazol-2-yl)-N '-benzoyl urea,a novel insect-growth regulator
J. CHEM. RES. -1998-478: Crystal structure of 1-(3,5-dichloro-2,4-difluorophenyl)-3-(2,6-difluorobenzoyl)urea,an inhibitor of chitin synthesis (SS,FF)
CHEM. J. CHINESE UNⅣ.-1994-224: Synthesis and bioactivities of novel trifluoromethylpyridine derivatives
CHINESE CHEM. LETT. -2004-7: Novel Analogues of -Terthienyl,Thienyl 1,3,4-Thia(oxa)diazoles as Potential Photoactivated Insecticides:Synthesis and Bioactivity (SS)
PESTICIDE BIOCHEM. PHYSIOLOGY-2004-42: Photolarvicidal effect of thienyl 1,3,4-thia(oxa)diazoles and their potential DNA photocleavage (SS)
ARKⅣOC-2003-141: Synthesis and insecticidal activity of 1,2,4-triazole derivatives
CHEM. LETT.-2001-54: A Novel and Practical Amination of 4,5-Dichloropyridazin-3-ones via Reduction with Hydrazine Hydrate
ORG. PREP. PROCEDURE INTL.-2000-571: A facile synthesis of aryl isothiocyanates from arylamines (SS)
ORG. PREP. PROCEDURE INTL.-1999-110: A facile synthesis of 3-chloro-4-(2 ',2 ',2 '-trifluoroethoxy)benzonitrile (FF)
研究方向3.化学生物技术与工程
CHEM. COMMUN.-2006-865: Baker's yeast-mediated enantioselective reduction of substituted fluorenones (FF)
CHEM. COMMUN.-2005-2338: A novel strategy for the preparation of arylhydroxylamines: chemoselective reduction of aromatic nitro compounds using bakers' yeast
CHEM. COMMUN.-2004-2339: A novel strategy for the preparation of arylhydroxylamines: chemoselective reduction of aromatic nitro compounds using bakersu2019 yeast
APPL. MICROBIO. BIOT.-2005-98: A novel synthetic fluoro-containing jasmonate derivative acts as a chemical inducing signal for plant secondary metabolism (FF)
APPL. MICROBIOL. BIOT.-2006-164: Novel synthetic 2,6-dichloroisonicotinate derivatives as effective elicitors for inducing the biosynthesis of plant secondary metabolites
APPLIED MICROBIO.BIOTECH.-2006-298: Efficient induction of ginsenoside biosynthesis and alteration of ginsenoside heterogeneity in cell cultures of Panax notoginseng by using chemically synthesized 2-hydroxyethyl jasmonate
BIOORG. MED. CHEM. LETT.-2005-1769: Novel 2-aminothiazonaphthalimides as visible light activatable photonucleases: effects of intercalation,heterocyclic-fused area and side chains (SS)
BIOORG. MED. CHEM. LETT.-2003-3513: Thiadiazole: A new family of intercalative photonuclease with electron transfer and radical mechanisms (SS,FF)
BIOORG. MED. CHEM. LETT.-2004-2665: Highly-efficient DNA photocleavers with long wavelength absorptions: thio-heterocyclic fused naphthalimides containing aminoalkyl side chains (SS)
BIOORG. MED. CHEM. LETT.-2004-2335: N-aroyloxylthioxo-naphthalimides as DNA photocleavers of aroyloxyl oxygen radicals: synthesis,evaluation,and substituents' effect (SS)
BIOORG. MED. CHEM. LETT.-2004-4755: Novel fluoro- and hydroxyl-containing jasmonate derivatives as highly efficient elicitors in suspension cultures of Taxus chinensis (FF)
BIOORG. MED. CHEM. LETT.-2006-803: Hydrolysis of plasmid DNA and RNA by amino alkyl naphthalimide as metal-free artificial nuclease (SS)
BIOORG. MED. CHEM.-2006-2935: Novel fluorescent markers for hypoxic cells of naphthalimides with two heterocyclic side chains for bioreductive binding
BIOORG. MED. CHEM.-2006-23: Eliminating nucleic acids contaminants by hydrogen peroxide-induced free radicals during the preparation of proteins (SS)
BIOTECH. BIOENG-2005-516: Highly efficient strategy for enhancing taxoid production by repeated elicitation with a newly synthesized jasmonate in fed- batch cultivation of Taxus chinensis cells
BIOTECH. BIOENG.-2004-809: Novel chemically synthesized hydroxyl-containing jasmonates as powerful inducing signals for plant secondary metabolism
BIOTECH. BIOENG.-2004-595: Novel synthetic jasmonates as highly efficient elicitors for taxoid production by suspension cultures of Taxus chinensis
BIOTECH. PROGR.-2006-331: Novel chemically synthesized salicylate derivative as an effective elicitor for inducing the biosynthesis of plant secondary metabolites
BIOTECH. AND BIOPROCESS ENGI.-2005-162: Efficient elicitation of ginsenoside biosynthesis in cell cultures of Panax notoginseng by using self-chemically-synthesized jasmonates
BIOCHEM. ENGINEERING. J.-2006-23: Eliminating nucleic acids contaminants by hydrogen peroxide-induced free radicals during the preparation of proteins
TETRAHEDRON LETT.-2004-1247: Naphthalimide-thiazoles as novel photonucleases: molecular design,synthesis,and evaluation (SS)
TETRAHEDRON-2005-11264: Versatile acenaphtho[1,2-b]pyrrol-carbonitriles as a new family of heterocycles: diverse Snar(H)H reactions,cytotoxicity and spectral behavior (SS)
DYES AND PIGMENTS-1999-139: Naphthalimide hydroperoxides as photonucleases: substituent effects and structural basis.
主要兼职
Journal of Fluorine Chemistry 国际编委
Pesticide Physiology and Biochemistry 国际编委
中国化工学会 副理事长
德国洪堡基金会(A.v.H/ Ambassador Scientist) 大使科学家
英国皇家化学会(Royal Society of Chemistry) 会士 (Fellow)
亚洲及太平洋化工联盟 (APCChE) 主席 (President)
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